Premium
Analysis of glycosphingolipids of human head and neck carcinomas with comparison to normal tissue
Author(s) -
Bolot G.,
David M. J.,
Taki T.,
Handa S.,
Kasama T.,
Richard M.,
Pignat J. C.,
Thomas L.,
Portoukalian J.
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800203632
Subject(s) - lactosylceramide , glycosphingolipid , glycolipid , ganglioside , head and neck , sialic acid , chemistry , ceramide , sphingomyelin , biochemistry , pathology , biology , medicine , membrane , apoptosis , surgery
Abstract Glycosphingolipids of head and neck carcinomas from six tumor‐bearing patients were analyzed and compared to those of normal tissue from similar areas. The total glycosphingolipid content and the lipid‐bound sialic acid were much higher in carcinomas than in normal tissue. Major neutral glycolipids were glucosylceramide, lactosylceramide, trihexosylceramide and paragloboside. Sulfatides were seen only in extracts from normal tissue which also showed a rather simple ganglioside pattern with #GM3 and GD3 as major species, whereas tumors showed additional species such as GM2 and GD2, along with a strong increase in LM1, GM1, GDla and GT1b.