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Dual effect of 2‐deoxy‐D‐glucose tetraacetate upon glucose‐induced insulin release
Author(s) -
Malaisse Willy J.,
Flores Luis E.,
Kadiata Marcel M.
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800202812
Subject(s) - medicine , endocrinology , insulin , chemistry , diabetes mellitus , islet , pancreatic islets , carbohydrate , blood sugar regulation
The effect of 2‐deoxy‐D‐glucose tetraacetate upon glucose‐stimulated insulin release was explored in pancreatic islets from either normal or hereditary diabetic rats. At a high concentration (10 mM), it decreased the secretory response to D‐glucose, such an inhibitory effect being more marked in the case of the α‐ than β‐anomer of the ester. At lower concentrations (0.19 to 1.7 mM), however, 2‐deoxy‐D‐glucose tetraacetate augmented insulin secretion evoked by 8.3 mM D‐glucose, with again a preference for the α‐anomer of the ester. In relative terms, such an enhancing action was more marked in Goto‐Kakizaki than normal rats. Hence, it is proposed that selected esters of non‐nutrient carbohydrates could be used as insulinotropic tools in the treatment of non‐insulin‐dependent diabetes mellitus.