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Reductive dechlorination of DDT to DDD by rat blood
Author(s) -
Sugihara Kazumi,
Kitamura Shigeyuki,
Ohta Shigeru
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800202452
Subject(s) - reductive dechlorination , chemistry , environmental chemistry , toxicology , biology , organic chemistry , biodegradation
The present study provides evidence that the reductive dechlorination of DDT (p, p'‐dichlorodiphenyltrichloroethane) to DDD (p, p'‐dichlorodiphenyldichloroethane) mediated by rat blood proceeds in the presence of both a reduced pyridine nucleotide and aflavin. The reduction appears to proceed in two steps. The first step is reduction of a flavin such as FAD, FMN or riboflavin by NADPH or NADH, either enzymatically or nonenzymatically. The second step is nonenzymatic reductive dechlorination of DDT by the reduced flavin, catalyzed by the heme group of hemoglobin.