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Influence of phenoxyherbicides and their metabolities on the form of oxy‐and deoxyhemoglobin of vertebrates
Author(s) -
Bukowska Bozena,
Reszka Edyta,
Duda Wirgiliusz
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800202422
Subject(s) - medicine , chemistry
The effect of phenoxyherbicides and their metabolites on the structure of oxy‐ and deoxyhemoglobin was studied by using different doses and times of incubation of hemoglobin with the herbicide. It was ascertained that among the investigated hemoglobins the most sensitive was carp oxyhemoglobin incubated with 2,4‐D (2,4‐dichlorophenoxyacetic acid) and the least sensitive was human hemoglobin. Comparing the toxicity of 2,4‐D, MCPA (2‐methyl‐4‐chlorophenoxyacetic acid), 2,4‐DCP (2,4‐dichlorophenol), 2,4‐DMP (2,4‐dimethylphenol) it was found that the highest decrease occurred in bovine hemoglobin incubated with 2,4‐DMP. The phenoxyherbicides caused stabilization of the structure of T‐deoxyhemoglobin in vitro, in that they decreased the oxygen affinity with a simultaneous increase in methemoglobin concentration.