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Effects of ethanol ingestion on insulin binding to rat leydig cells
Author(s) -
Srikanth V.,
Shanthakumari D.,
Sudha S.,
Govindarajulu P.,
Balasubramanian K.
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800202402
Subject(s) - ethanol , endocrinology , insulin , medicine , ingestion , leydig cell , alcohol , testosterone (patch) , chemistry , hormone , biochemistry , luteinizing hormone
Effects of ethanol treatment and its withdrawal on insulin binding to isolated rat Leydig cells were Studied. Mature rats were given ethanol by gastric intubation for 30 days at a dose of 3.0g/kg body weight, twice daily, as a 25% (v/v) aqueous solution and treatment was withdrawn for the subsequent 30 days in an another group. Ethanol treatment markedly increased serum insulin and reduced the 125I‐insulin binding to Leydig cells and the activities of Leydig cellular steroidogenic enzymes such as 3β‐HSD and 17β‐HSD. Withdrawal of ethanol treatment restored these changed values to their normal levels. The results suggest the possible involvement of subnormal insulin actions, as that of LH, in the ethanol‐induced impairment of Leydig cellular steroidogenesis and the resulting hypoandrogenization associated with alcohol abuse.