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Thyroid hormone, all‐trans retinoic acid, and 9‐cis retinoic acid functioned as negative modulators of the effect of glucocorticoid on induction of α1‐acid glycoprotein mRNA in RLN‐10 cells
Author(s) -
Li Xiaoman,
Sumi Tomoyuki,
Matsukawa Toru,
Nakanishi Yoshinobu,
Ohba Yoshiki
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800202382
Subject(s) - retinoic acid , medicine , endocrinology , hormone , gene expression , glucocorticoid , chemistry , in vitro , retinoic acid inducible orphan g protein coupled receptor , thyroid , glycoprotein , gene , biology , retinoic acid receptor , biochemistry
The expression of acute‐phase protein genes is controlled by many factors, such as IL‐1, IL‐6, glucocorticoids, thyroid hormone (T3), and retinoic acids. We studied the interaction of T3, glucocorticoids, all‐trans retinoic acid (RA), and 9‐cis retinoic acid (9cRA) on the expression of the rat α1‐acid glycoprotein (AGP) gene in vitro. Dexamethasonc (Dex) activated AGP gene expression in a rat liver derived cell line, RLN‐10. Although T3, RA, and 9cRA by themselves had no effect on AGP production, they reduced the response to Dex of the AGP gene.