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Spirulina maxima prevents induction of fatty liver by carbon tetrachloride in the rat
Author(s) -
TorresDurán P. V.,
MirandaZamora R.,
ParedesCarbajal M. C.,
Mascher D.,
DíazZagoya J. C.,
JuárezOropeza M. A.
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800201832
Subject(s) - carbon tetrachloride , spirulina (dietary supplement) , chemistry , fatty liver , cholesterol , ccl4 , intraperitoneal injection , biochemistry , medicine , endocrinology , biology , organic chemistry , raw material , disease
The aim of the present work was to assess the capacity of Spirulina maxima to prevent fatty liver development induced in rats by an intraperitoneal single dose (1ml/kg) of carbon tetrachloride. Liver and serum lipids were quantified two or four days after treatment with this agent. Liver lipid concentration did not differ in rats fed on a purified diet with or without Spirulina. However, after carbon tetrachloride treatment, liver triacylglycerols were significantly lower in rats fed on a diet with Spirulina 5% than in rats without Spirulina in their diet (P < 0.05). Furthermore, the increased liver cholesterol values, induced by carbon tetrachloride treatment, were not observed in rats that received Spirulina. These results support the potential hepatoprotective role of Spirulina.