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Molecular cloning of a novel chemokine receptor‐like gene from early stage chick embryos
Author(s) -
Gupta Shalley K.,
Pillarisetti Kodandaram,
Gray Samantha L.,
Stadel Jeffrey M.
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800201722
Subject(s) - cloning (programming) , biology , gene , molecular cloning , embryo , chemokine receptor , microbiology and biotechnology , chemokine , genetics , receptor , computational biology , gene expression , computer science , programming language
Proliferation, differentiation and regulated trafficking of cells are the hallmarks of development and embryogenesis. This led us to speculate a role for chemokines and their receptors in this process. Here, we report the molecular cloning of AvCRL1, a novel member of the G‐protein coupled receptor family from early stage 3 days old chick embryos. While the function and ligand for this receptor remain unknown, its sequence and gene structure indicates that it is most related to the family of chemokine receptors, with highest homology to the virally induced human BLR‐1 and the CXCR3 or γIP‐10/Mig‐1 receptors.