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Protective role of superoxide dismutase in iron toxicity in yeast
Author(s) -
Wisnicka Renata,
Krzepiłko Anna,
Wawryn Jarosław,
Krawiec Zdzisława,
Bilinski Tomasz
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800201672
Subject(s) - superoxide dismutase , yeast , peroxidase , ferrous , toxicity , biochemistry , chemistry , oxygen toxicity , superoxide , reactive oxygen species , cytochrome c , enzyme , biology , oxygen , mitochondrion , organic chemistry
It has been found that yeast mutants deficient in cytosolic superoxide dismutase CuZnSOD are hypersensitive to ferrous iron. In contrast mutants that are deficient in catalases and cytochrome c peroxidase do not differ from the standard strain in this respect. These findings suggest that iron toxicity may depend on the redox status of the cell. They also shed light on the role of superoxide dismutases in preventing the toxic effects of oxygen.