Down‐regulation of protein kinase C‐α detected in human colorectal cancer | Zendy

Suga Kenji | Zendy; Sugimoto Isamu | Zendy; Ito Hisao | Zendy; Hashimoto Eikichi | Zendy

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Down‐regulation of protein kinase C‐α detected in human colorectal cancer

Author(s) -

Suga Kenji,

Sugimoto Isamu,

Ito Hisao,

Hashimoto Eikichi

Publication year - 1998

Publication title -

iubmb life

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.132

H-Index - 113

eISSN - 1521-6551

pISSN - 1521-6543

DOI - 10.1080/15216549800201552

Subject(s) - colorectal cancer , kinase , cancer research , protein kinase a , chemistry , cancer , microbiology and biotechnology , biology , genetics

The down‐regulation of protein kinase C (PKC) was examined by Western blot procedure on about 30 tissue samples derived from human colorectal cancer and the corresponding normal mucosa. PKC‐α down‐regulation was detected in 60% of the cancer tissues compared with the respective normal mucosa and was observed in a higher frequency with the tissues under more advanced cancer stages. However, the frequencies of the down‐regulation of PKC‐δ and PKC‐ζ were lower than that of PKC‐α. These results suggest that a decreased level of PKC‐α may affect the cell growth and tumor promotion in colorectal tissue.

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