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Down‐regulation of protein kinase C‐α detected in human colorectal cancer
Author(s) -
Suga Kenji,
Sugimoto Isamu,
Ito Hisao,
Hashimoto Eikichi
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800201552
Subject(s) - colorectal cancer , kinase , cancer research , protein kinase a , chemistry , cancer , microbiology and biotechnology , biology , genetics
The down‐regulation of protein kinase C (PKC) was examined by Western blot procedure on about 30 tissue samples derived from human colorectal cancer and the corresponding normal mucosa. PKC‐α down‐regulation was detected in 60% of the cancer tissues compared with the respective normal mucosa and was observed in a higher frequency with the tissues under more advanced cancer stages. However, the frequencies of the down‐regulation of PKC‐δ and PKC‐ζ were lower than that of PKC‐α. These results suggest that a decreased level of PKC‐α may affect the cell growth and tumor promotion in colorectal tissue.