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Angiotensin II and related peptides alter liposomal membrane fluidity
Author(s) -
Brailoiu Eugen,
Margineanu Anca,
Miyamoto Michael D.
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800201222
Subject(s) - membrane fluidity , vesicle , fluorescence anisotropy , chemistry , angiotensin ii , bilayer , phospholipid , phosphatidylcholine , liposome , membrane , biophysics , lipid bilayer , receptor , biochemistry , biology
Abstract We investigated the effects of angiotensinogen (Ang), angiotensin I (Ang I), and angiotensin II (Ang II) on the fluidity of phosphatidylcholine vesicles. Changes in fluidity were assessed by changes in anisotopy values calculated from fluorescence polarization measurements. All three compounds produced an increase in membrane fluidity when localized inside the phosphatidylcholine vesicles. When placed outside the vesicles, Ang II increased bilayer rigidity (decreased fluidity), whereas Ang and Ang I produced no effect. These results suggest the possibility that these peptides may alter the fluidity of cell membranes by a direct action on the phospholipid bilayer, which may in turn interfere with receptor‐mediated effects.

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