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RAPD analysis of Candida albicans strains recovered from different immunocompromised patients (ICP) reveals an apparently non‐random infectivity of the strains
Author(s) -
Gyanchandani Anita,
Khan Zafar K.,
Farooqui Nuzhat,
Goswami Mamta,
Ranade Shirish A.
Publication year - 1998
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549800201022
Subject(s) - candida albicans , rapd , biology , microbiology and biotechnology , corpus albicans , upgma , strain (injury) , infectivity , virulence , virology , genetic variation , genetics , virus , medicine , genetic diversity , gene , population , environmental health , anatomy
The opportunistic imperfect fungus Candida albicans causing life‐threatening infections in immunocompromised patients (ICP), especially in HIV‐positive cases, is recognized to be one of the most important nosocomial pathogens in the recent decades. The extent of strain‐to‐strain variation within a species and its relationship to the ability of the organism to colonize or invade a specific group of patients or even a body site is, however, not well known. We have analysed 19 strains of C.albicans recovered from ICP at different locales and times, employing the RAPD technique. No two strains generated identical RAPD profiles with any of the 21 primers tested. Further, the UPGMA clustering of the strains seemingly reflected a certain relationship or non‐randomness in the infection of the patients with the strain of C.albicans vis‐a‐vis the immunocompromised status due to underlying disease such as diabetes, cancer, asthma and meningitis. These results may have a profound impact on the management of candidiasis, especially in the ICP.