Premium
Sheep testicular and epididymal angiotensin converting enzyme: inhibitions by captopril, lisinopril and enalapril
Author(s) -
Udupa E.G. Padmanabha,
Rao N. Mallikarjuna
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700204881
Subject(s) - lisinopril , captopril , enalapril , angiotensin converting enzyme , enalapril maleate , endocrinology , medicine , enzyme , renin–angiotensin system , pharmacology , chemistry , biochemistry , blood pressure
Inhibition of angiotensin converting enzyme(ACE) in presence of captopril(C), lisinopril(L) and enalapril(E) were investigated in testis and epididymis of sheep using Hip‐His‐Leu as substrate. Captopril, lisinopril and enalapril were competitive inhibitors of the enzyme from both tissues. Differences in the I50 and Ki values using these three inhibitors reflects the affinities of these inhibitors for the, ACE. In addition, the relative potencies of captopril, lisinopril and enalapril were different for testicular ACE(C > L > E) and epididymal ACE(L>C >E). This observation suggests differences between the active sites of the testicular and epididymal ACE which may reflect on their functions in vivo.