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Antitumor activity of conjugates of the oncofetal protein alpha‐fetoprotein and phthalocyanines in vitro
Author(s) -
Severin S. E.,
Posypanova G. A.,
Katukov V.Yu.,
Shmyrev I. I.,
Luzhkov Yu.M.,
Gerasimova G. K.,
Zhukova O. S.,
Vorozhtsov G. N.,
Kaliya O. L.,
Lukyanets E. A.,
Severin E. S.
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700204681
Subject(s) - conjugate , in vitro , cytotoxic t cell , chemistry , phthalocyanine , alpha (finance) , alpha fetoprotein , cobalt , toxicity , biochemistry , cancer research , biology , medicine , organic chemistry , mathematical analysis , construct validity , mathematics , nursing , hepatocellular carcinoma , patient satisfaction
The several conjugates of aluminium and cobalt complexes of phthalocyanines with human alpha‐fetoprotein have been synthesized. Their cytotoxic activity against tumor cells and human peripheral blood lymphocytes was studied. The experimental data demonstrate that the cytotoxic activity of alpha‐fetoprotein‐phthalocyanine conjugates against three types of tumor cells of various origin is much higher (for aluminium and cobalt complexes more than 1000 and 50 times, respectively) in comparison with phthalocyanines themselves. The application of phthalocyanines as conjugates with alpha‐fetoprotein makes it possible to markedly enhance the selective toxicity of phthalocyanines against human tumor cells.