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Mapping the common antigenic determinants in avidin and streptavidin
Author(s) -
Subramanian N.,
Adiga P. Radhakantha
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700204161
Subject(s) - epitope , polyclonal antibodies , antigen , streptavidin , avidin , biotinylation , antibody , linear epitope , biology , chemistry , microbiology and biotechnology , computational biology , biochemistry , genetics , biotin
An epitope scan analysis of the whole sequence of avidin and core streptavidin using polyclonal antibodies to these two antigens reveal the presence of multiple common epitopes in both the proteins. These antigenic determinants consist mostly of either identical or similar residues. The antibody recognition sites in both antigens are shown to be localized to homologous regions.