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Free radicals in the cerebrospinal fluid are associated with neurological disorders including mitochondrial encephalomyopathy
Author(s) -
Ihara Yuetsu,
Kibata Masayoshi,
Hayabara Toshiyuki,
Katayama Shizuo,
Konishi Hiroshi,
Miura Kenzo,
Kohno Masahiro,
Kawai Motoko,
Yokoi Isao,
Mori Akitane
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700203381
Subject(s) - cerebrospinal fluid , mitochondrial encephalomyopathy , radical , discontinuation , medicine , oxidative stress , lumbar puncture , lumbar , anesthesia , free radical theory of aging , chemistry , endocrinology , surgery , biochemistry , mitochondrial dna , gene
The free radical levels in the cerebrospinal fluid of 8 patients with neurological diseases and 9 undergoing lumbar anesthesia for surgery were measured. The ascorbate free radical level 10 min after lumbar puncture showed a positive correlation with the hydroxyl radical level. In the patient with mitochondrial encephalomyopathy, the levels of hydroxyl and ascorbate free radicals increased upon discontinuation of treatment and decreased upon its resumption, and the ascorbate free radical levels without therapy fell after lumbar puncture. The free radical levels in the cerebrospinal fluid may reflect the degree of oxidative stress in the central nervous system.