Premium
No influence of a single bout of exercise on urinary excretion of 8‐hydroxy‐deoxyguanosine in humans
Author(s) -
Sumida Satoshi,
Okamura Koji,
Doi Tatsuya,
Sakurai Masao,
Yoshioka Yasuyuki,
SugawaKatayama Yohko
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700203011
Subject(s) - deoxyguanosine , excretion , medicine , incremental exercise , endocrinology , oxidative stress , treadmill , 8 hydroxy 2' deoxyguanosine , urine , urinary system , physical exercise , bicycle ergometer , chemistry , heart rate , oxidative damage , blood pressure , dna oxidation
We investigated the effect of a single bout of intensive exercise on the excretion of 8‐hydroxy‐deoxyguanosine in the 24 h urine from healthy non‐smokers. We studied three exercise tests in Experiment 1; which consisted of incremental exercise to exhaustion on a treadmill in eleven male long distance runners. Experiment 2; which comprised incremental exercise until reaching exhaustion on abicycle ergometer in six male untrained subjects. Experiment 3; which consisted of a 20 km run by eleven male long distance runners. No differences in the urinary 8‐hydroxy‐deoxyguanosine excretion were obselwed from days 1 or 3 after each respective exercise regimen. However, significant increases in the plasma creatine kinase activity were observed at 24 h or 48 h after exercise, except for Experiment 2. Our results thus suggest that the oxidative stress during a single bout of intensive exercise does not result in an accumulation of oxidative DNA damage.