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The control of oxygen affinity in the three human embryonic haemoglobins by respiration linked metabolites
Author(s) -
Hofmann Oliver M.,
Brittain Thomas,
Wells Rufus M. G.
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700202961
Subject(s) - oxygen , embryonic stem cell , respiration , biochemistry , chemistry , biophysics , incubation , biology , anatomy , organic chemistry , gene
The effect of CO2, ATP and lactate ions on the oxygen affinity of the three human embryonic haemoglobins have been studied. CO2 lowers the affinity of both the adult and embryonic haemoglobins for oxygen, as does ATP. The ATP effect follows a simple binding process with an equilibrium constant in the mM range. Lactate ions have no effect on the oxygen equilibrium process, over the concentration range studied. These findings are discussed in terms of the likely physiological conditions experienced by human embryonic red blood cells.