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Menadione‐dependent reduction of tertiary amine N‐oxide by rat liver cytosol
Author(s) -
Kitamura Shigeyuki,
Tatsumi Kiyoshi
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700202661
Subject(s) - menadione , tertiary amine , chemistry , amine gas treating , cytosol , medicinal chemistry , biochemistry , enzyme , organic chemistry
This study demonstrates the menadione‐dependent reduction of imipramine N‐oxide, a tertiary amine N‐oxide, to imipramine by rat liver cytosol in the presence of NADH or NADPH. A mechanism for the cytosolic reduction of the tertiary amine N‐oxide is proposed. Menadione is converted to its reduced form by a menadione‐reducing enzyme such as DT‐diaphorase and the reduced pyridine nucleotide, followed by reduction of the tertiary amine N‐oxide to the amine by the heme group of catalytic hemoproteins in the presence of reduced menadione as an electron donor.