Premium
Differences in aldehyde oxidase activity in cytosolic preparations of human and monkey liver
Author(s) -
Sugihara Kazumi,
Kitamura Shigeyuki,
Tatsumi Kiyoshi,
Asahara Toshimasa,
Dohi Kiyohiko
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700202241
Subject(s) - aldehyde oxidase , benzaldehyde , human liver , isozyme , aldehyde , biochemistry , substrate (aquarium) , cytosol , enzyme , oxidase test , chemistry , biology , xanthine oxidase , catalysis , ecology
This study presents data showing individual differences in aldehyde oxidase activity in human and monkey liver cytosols. When assayed with benzaldehyde as a substrate, a significant inter‐subject variation in the activity was found in the human liver preparations. When assayed with N1‐methylnicotinamide as a substrate, the inter‐subject variation of the activity was also observed, but to a lesser extent compared with that of the activity with benzaldehyde. Similarly, variations in aldehyde oxidase activity were found in the monkey liver preparations when assayed with benzaldehyde or N1‐methylnicotinamide. The present study suggested that at least two isozymes of aldehyde oxidase exist in the human liver preparations.