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Mutagenic and genotoxic activities of four pesticides: Captan, foltaf, phosphamidon and furadan
Author(s) -
Saxena Sangeeta,
Ashok B. T.,
Musarrat Javed
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700202211
Subject(s) - phosphamidon , captan , toxicology , pesticide , ames test , chemistry , mutagen , biology , salmonella , genetics , dna , bacteria , dimethoate , agronomy
The mutagenic and genotoxic potential of four pesticides viz. captan, foltaf, phosphamidon and furadan was evaluated by the Ames mutagenicity assay and their DNA damaging ability on radiation repair defective E. coli K‐12 strains respectively. The mutagenic spectrum revealed captan to be most mutagenic in the absence of metabolic activation, while the presence of S9 mix led to an attenuated mutagenic response. Foltaf, phosphamidon and furadan were detected as relatively weaker mutagens. A significant decrease in the survival of SOS defective mutants, recA, lexA and pol‐ of E. coli was observed as compared to their wild‐type counterparts in the presence of the pesticides. The role of SOS repair genes gains further support from the Salmonella strains triggering the error‐prone SOS response.