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Membrane permeability transition as induced by dysfunction of the electron transport chain
Author(s) -
Chávez Edmundo,
Meléndez Esperanza,
Zazueta Cecilia,
ReyesVivas Horacio,
Perales Sofía G.
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700202021
Subject(s) - permeability (electromagnetism) , membrane , electron transport chain , chain (unit) , electron , chemistry , materials science , chemical physics , physics , biochemistry , quantum mechanics
The results in this paper indicate that mitochondrial permeability transition is activated by dysfunction of the respiratory chain caused by anaerobiosis, exhaustion of the oxidative substrate, and antimycin A, in the presence of 100 μM Ca2+. Membrane damage coincides with the collapse of the electric gradient. The opening of the non‐selective pore is prevented by cyclosporin A.