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Enhanced production of LTB4 and free radicals in rat lung by exhaustive physical exercise
Author(s) -
Kumar T. Charles,
Reddy K. Veera,
Anuradha D.,
Reddanna P.
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700201681
Subject(s) - lung , oxidative stress , arachidonic acid , radical , chemistry , endogeny , inflammation , lipoxygenase , microsome , medicine , leukotriene b4 , endocrinology , biochemistry , enzyme
Abstract Leukotrienes formed by the action of 5‐lipoxygenase on arachidonic acid are a group of endogenous compounds active in hypersensitivity reactions and inflammation. In this report the formation of LTB4 from LTA4 was measured by incubating lung microsomes from normal and exercised rats to determine whether LTB4 may have a role in the mediation of exercise‐induced oxidant stress. Exhaustive exercise in the form of swimming results in the enhanced production of LTB4 in lung microsomes. Further, free radicals measured by ESR spectroscopy were also significantly increased in lung tissue from exercised rats. These results suggest a role for LTB4 in the mediation of lung tissue damage during exercise‐induced oxidative stress.