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Erythrophagocytosis and its relation to band 3 clustering in chronic myelogenous leukemia
Author(s) -
Das Amit K.,
Sinha Ajay K.,
Basu Joyoti
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700201561
Subject(s) - chronic myelogenous leukemia , band 3 , leukemia , glutathione , cluster analysis , k562 cells , erythrocyte membrane , chemistry , membrane , immunology , medicine , biochemistry , computer science , machine learning , enzyme
Band 3, a major erythrocyte membrane glycoprotein, undergoes topographic redistribution leading to enhanced clustering, in chronic myelogenous leukemia (CML). This is probably due to the binding of heme compounds to the CML erythrocyte membrane resulting from depletion of cellular levels of reduced glutathione (GSH). Band 3 clustering appears to be one of the factors associated with increased erythrophagocytosis in CML