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Alterations in eighteen‐carbon saturated, monounsaturated and polyunsaturated fatty acid peroxisomal oxidation in mouse brain during development and aging
Author(s) -
Bourre J. M.,
Piciotti M.
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700201481
Subject(s) - peroxisome , polyunsaturated fatty acid , linoleic acid , oleic acid , stearic acid , weaning , chemistry , biochemistry , fatty acid , beta oxidation , arachidonic acid , linolenic acid , medicine , endocrinology , biology , organic chemistry , enzyme , gene
Peroxisomal oxidation was measured in mouse brain homogenate by adding cyanide to the test tube (which inhibits mitochondrial oxidation). Eighteen‐carbon fatty acids (saturated, monounsaturated and polyunsaturated ware oxidized by brain peroxisomes. At nearly all ages, oxidation of oleic acid was higher (about 2 fold) than oxidation of other eighteen‐carbon fatty acids. In contrast to other fatty acids, stearic acid oxidation decreased regularly up to weaning (6 fold) and was stable thereafter. Oleic acid oxidation increased up to weaning, decreased during development up to day 70 and remained subsequently nearly stable. Linoleic acid and alpha‐linolenic acid oxidation increased up to weaning, decreased up to day 105 and was nearly stable thereafter. Alpha‐linolenic acid oxidation about was two fold lower than linoleic acid oxidation. Interestingly, peroxisomal oxidation for all fatty acids examined declined during aging, between day 365 and day 450.