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The antioxidant properties of thioctic acid: Characterization by cyclic voltammetry
Author(s) -
Chevion S.,
Hofmann M.,
Ziegler R.,
Chevion M.,
Nawroth P. P.
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700201331
Subject(s) - thioctic acid , cyclic voltammetry , characterization (materials science) , chemistry , antioxidant , voltammetry , nanotechnology , materials science , electrochemistry , organic chemistry , lipoic acid , electrode
Thioctic acid (TA) level and its antioxidant capacity were monitored by cyclic voltammetry (CV), in solution and in human plasma. A linear correlation between the anodic wave current Ia at 900 mV and [TA] was obtained. This indicates that TA, commonly found in human plasma, is an antioxidant component characterized by a potential E1/2=900 mV and constitute, at least in part, the second anodic wave of the CV tracing. When plasma from diabetic patients was analyzed by CV, those patients under treatment with TA showed higher Ia than others not taking the drug. When the patients under treatment with TA were divided into groups according to the severity of their nephropathy, or according to the severity of their total complication count, Ia levels representing TA were significantly higher in those patients with more severe complications.