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Modulation of muscarinic receptor‐stimulated phosphoinositide breakdown by sulfhydryl group modification is a general response in different rat brain regions and depends on the stage of brain development
Author(s) -
Balduini Walter,
Cattabeni Flaminio,
Cantoni Orazio
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201932
Subject(s) - muscarinic acetylcholine receptor , modulation (music) , stage (stratigraphy) , chemistry , receptor , neuroscience , biophysics , endocrinology , medicine , biology , biochemistry , physics , paleontology , acoustics
In a previous study we reported that muscarinic receptor‐stimulated phosphoinositide breakdown in rat cortical slices is significantly reduced by modification of critical thiols located at the post‐receptor level [1]. We have now extended this observation by investigating whether this effect is a general response in different brain areas and is differentially regulated, within the cortex, in the neonatal and adult brain. Experimental results have demonstrated that indeed the effect of sulfhydryl group modification on muscarinic receptor‐stimulated phosphoinositide breakdown appears to be mediated by a general mechanism operative in different brain regions (cortex, hippocampus and striatum). In addition, this response is more pronounced in the early stages of brain development, when muscarinic receptor agonists lead to the highest inositol phosphate accumulation.