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Effect of a cholesterol‐rich diet on the excitability of rabbit aorta
Author(s) -
Wong Kai K.
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201882
Subject(s) - depolarization , aorta , stimulation , cholesterol , medicine , endocrinology , chemistry , rabbit (cipher) , biophysics , biology , statistics , mathematics
The level of plasma total cholesterol in rabbits after 8‐week feeding on a cholesterol‐rich diet was raised significantly. The excitability of the rabbit aorta in response to the depolarizing agent KC1 was enhanced, demonstrating an increased sensitivity to KC1 stimulation as well as an increase of the KC1‐induced maximum tension. It is speculated that 7 weeks of hypercholesterol state may vary the membrane lipid composition, enhancing the aortic excitability in response to depolarizing agent.