Tempace and troxyl‐novel synthesized 2,2,6,6‐tetramethylpiperidine derivatives as antioxidants and radioprotectors

Two novel 2,2,6,6‐tetramethylpiperidine derivatives (Tempace and Troxyl) were synthesized and their capacity to act as scavengers of superoxide, inhibitors of iron and ascorbate‐driven Fenton reaction and radioprotectors was tested. The possibility for one‐electron oxidation of novel compounds by heme‐ferryl species was also examined. The results clearly indicate that Tempace and Troxyl are acting as promising antioxidants and radioprotectors thus providing a base for further investigations and pharmacological applications.