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A novel cDNA encoding for a lim domain protein located at human chromosome 14q32 as a candidate for leukemic translocation
Author(s) -
Tsui Stephen Kwok Wing,
Chan Peggy Pik Kwan,
Cheuk Chin Wah,
Liew Choong Chin,
Waye Mary Miu Yee,
Fung Kwok Pui,
Lee Cheuk Yu
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201831
Subject(s) - complementary dna , open reading frame , chromosomal translocation , lim domain , zinc finger , microbiology and biotechnology , clone (java method) , fluorescence in situ hybridization , biology , amino acid , chromosome , peptide sequence , genetics , gene , transcription factor
A full‐length cDNA clone encoding a zinc finger protein was isolated and sequenced. This full‐length clone consists of 728 bp and has a predicted open reading frame (ORF) encoding 208 amino acids. The ORF of this polypeptide codes for the human cysteine‐rich protein 2 (HCRP2) and has an amino acid sequence that is 92.8% identical to its rat homolog (RCRP2). HCRP2 was mapped to chromosome 14q32, which is a hot spot of translocation in tumor development, by fluorescent in situ hybridization (FISH).