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Effects of ubiquinone enriched diet on deterioration of mitochondrial respiratory function caused by fried beef derived mutagenic factor in rats
Author(s) -
Sugiyama Satoru,
Yamada Koujirou,
Hayakawa Mika,
Esumi Hiroyasu,
Ozawa Takayuki
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201792
Subject(s) - mitochondrion , respiratory system , chemistry , medicine , endocrinology , diaphragm (acoustics) , biochemistry , food science , biology , physics , acoustics , loudspeaker
2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), a potent mutagenic agent produced during thermal processing of meats, shows detrimental effects on mitochondrial respiratory function. Effects of dietary ubiquinone‐10 was examined on PhIP‐induced mitochondrial respiratory dysfunction in rats. Rats fed with 0.2% ubiquinone‐10 diet mitigated the PhIP‐induced decrease in mitochondrial complex I activities observed in rat heart, diaphragm, and psoai major. Therefore, dietary anti‐oxidants such as ubiquinone‐10 could cancel out the unfavorable effects of PhIP and contribute to the preservation of mitochondrial function.