Premium
Antioxidant property of Fructus Momordicae extract
Author(s) -
Shi Honglian,
Hiramatsu Midori,
Komatsu Makiko,
Kayama Takamasa
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201753
Subject(s) - tbars , chemistry , antioxidant , lipid peroxidation , thiobarbituric acid , radical , xanthine oxidase , hypoxanthine , dpph , hydroxyl radical , biochemistry , cortex (anatomy) , enzyme , neuroscience , biology
The antioxidant effect of Fructus Momordicae extract, FME (mogrosides 75‐80%), was studied. FME reduced the stable free radical 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and scavenged superoxide radicals (O2‐) generated by a hypoxanthine and xanthine oxidase system. It also scavenged hydroxyl radicals (⊎OH) generated by Fenton reaction. In addition, FME inhibited Fe(II) induced lipid peroxidation in rat cortex homogenates in a dose‐dependent manner, as indicated by decreased thiobarbituric acid‐reactive substances (TBARS) formation. Oral administration of FME inhibited TBARS and malonaldehyde (MDA) formation in the ipsilateral cortex 30 min after iron‐salt injection into the left cortex of rat. FME showed inhibitory effect on 4‐hydroxy‐2(E)‐nonenal (4‐HNE) formation induced by Fe(III) injection into the rat cortex. These data suggest that Fructus Momordicae extract has an antioxidant activity against free radicals and lipid peroxidation.