Premium
Identification and cloning of a novel type I sering / threonine kinase receptor of the TGF‐β / BMP superfamily in rat prostate
Author(s) -
Kang Yong,
Reddi A. Hari
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201623
Subject(s) - biology , microbiology and biotechnology , protein kinase domain , acvr2b , map2k7 , threonine , c raf , kinase , protein kinase a , mitogen activated protein kinase kinase , biochemistry , serine , receptor , cyclin dependent kinase 2 , tgf beta signaling pathway , phosphorylation , gene , mutant
A cDNA clone encoding a new member of the type I serine / threonine kinase receptors of the TGF‐β / BMP superfamily was isolated from a rat prostate cDNA library. The predicted sequence of the encoded protein is 493 amino acids with a molecular weight of 55 kDa. It contains a putative cysteine rich extracellular domain, a transmembrane domain, a conserved type I receptor GS domain and a cytoplasmic serine / threonine kinase domain. The kinase domain shares 80% homology with that of ALK‐4 and ALK‐5 whose ligands are activin and TGF‐β. Northern blot analysis revealed that this prostate serine / threonine kinase receptor I (PSKR‐I) is highly expressed in rat dorsolateral prostate, coagulating gland (anterior prostate), cerebellum and adipose tissue.