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Inhibition of mitochondrial cytochrome c oxidase by dicarbanonaborates
Author(s) -
Drahota Zdeněk,
Vrbacký Marek,
Rauchová Hana,
Kalous Martin
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201462
Subject(s) - cytochrome c oxidase , cytochrome c1 , chemistry , mitochondrion , biochemistry , cytochrome c , coenzyme q – cytochrome c reductase , inner mitochondrial membrane , enzyme , cytochrome b , oxidase test , cytochrome , mitochondrial dna , gene
Dicarbanonaborates inhibit the mitochondrial cytochrome c oxidase activity. In contrast to mitochondrial ATPase or glycerol phosphate dehydrogenase, inhibition of cytochrome c oxidase was not competitive and the residual, drug‐insensitive activity was higher. These results indicate that dicarbanonaborates inhibit various mitochondrial membrane‐bound enzymes through different mechanisms.