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What regulates respiration in mitochondria?
Author(s) -
Korzeniewski Bernard
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201451
Subject(s) - adenylate kinase , oxidative phosphorylation , mitochondrion , phosphorylation , energy charge , respiration , atp synthase , atp–adp translocase , cellular respiration , bioenergetics , biophysics , regulator , respiration rate , biochemistry , chemistry , microbiology and biotechnology , biology , inner mitochondrial membrane , receptor , botany , enzyme , gene
A (nearly) linear dependence of the respiration rate on a given parameter value was proposed as the criterion for considering this parameter to be an efficient regulator of respiration in mitochondria. A number of possible candidates was tested using the dynamic model of oxidative phosphorylation developed previously, among others ADP, the ATP/ADP ratio, external phosphorylation potential and Atkinson's adenylate energy charge. Only the external phosphorylation potential log(ATP/ADP*Pi) was found to fulfil the above‐mentioned criterion and thus it was proposed to be the parameter which “actually” regulates oxidative phosphorylation in mitochondria.