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Normalization of immune response and phosphoinositide fatty acid composition of peripheral blood lymphocytes in an alcoholic patient after alcohol abstinence
Author(s) -
Stefanini G. F.,
Castelli E.,
Foschi F. G.,
Marsigli L.,
Addolorato G.,
Celadon M.,
Biagi P. L.,
Bordoni A.,
Gasbarrini G.,
Hrelia S.
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201391
Subject(s) - abstinence , alcohol , fatty acid , stimulation , immune system , cd3 , lymphocyte , medicine , endocrinology , immunology , biochemistry , chemistry , cd8 , psychiatry
After 10 months of alcohol abstinence a malnourished alcoholic patient improved his nutritional status. The analysis of peripheral blood lymphocyte response to mitogenic stimulation with the antibody anti‐CD3 and of the fatty acid composition of the (poly)‐phosphoinositide fraction derived from lymphocytes revealed: 1) a similar [3H]‐thymidine uptake as in control (non‐drinker) subjects; 2) a similar relative molar content of the main fatty acids in the (poly)‐phosphoinositides as in control subjects. Alcohol abstinence can normalize both the parameters, which are greatly altered during alcohol abuse. This suggests a link between nutritional status and lymphocyte responsiveness via phosphoinositide fatty acid composition.