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Erythrocyte membrane Na,K ATP ase activity can be a marker of liver histopathology
Author(s) -
Kuralay Filiz,
Tanyalçin Tijen,
Kutay Fatma,
Yuce Gül,
Ersoz Galip,
Batur Yücel
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201373
Subject(s) - cirrhosis , medicine , phospholipid , glutathione , hepatitis , endocrinology , chemistry , fibrosis , histopathology , biology , biochemistry , pathology , enzyme , membrane
Erythrocyte membrane Na+,K+; Ca2+ ATP ase activities, cholesterol (CH) phospholipid (PL) composition and erythrocyte glutathione (GSH) contents were determined in controls, in patients with chronic active hepatitis and liver cirrhosis. Na+,K+ ATP ase activities were significantly (P<0.0001) less in patients with chronic active hepatitis and liver cirrhosis (n=8, 0.102 ± 0.02 µmol P/mg protein/hour; n=8, 0.081 ± 0.02 µmol P/mg protein/hour) than in controls (n=10, 0.219 ± 0.05). Histopathological analysis of liver sections obtained from patients with chronic active hepatitis (n=3) and liver cirrhosis (n=2) correlated well with erlthrocyte biochemical findings. There was a significant negative correlation between Na+,K+ ATP ase activity and portal fibrosis (P<0.05, r=‐8680). However, further experiments performed on larger study populations are needed to better elucidate this correlation. Therefore, Na+,K+ ATP ase activity measurement can be reliable assessment of liver fibrosis.