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Spontaneously hypertensive rats: Eicosa‐8,11,14‐trienoic acid metabolism and arachidonic acid biosynthesis
Author(s) -
de Catalfo Graciela E. Hurtado,
Dumm Irma N.T. de Gómez
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201363
Subject(s) - arachidonic acid , medicine , endocrinology , polyunsaturated fatty acid , metabolism , chemistry , microsoma , fatty acid , microsome , fatty acid metabolism , enzyme , arachidonic acid metabolism , biosynthesis , lipid metabolism , biochemistry , biology
Delta 9, Δ 6 and Δ5 desaturation activity and the thioesterification of eicosa‐8,11,14‐trienoic acid (DGLA) were measured in spontaneously hypertensive rats (SHR) compared to normotensive controls (WKY). SHR exhibited lower levels in the long‐chain fatty acyl‐CoA (LCFA) synthetase and in Δ6 and Δ5 desaturase activities in liver. The enzymatic activity changes were reflected on the fatty acid composition of liver microsomes. In testis, the thioesterification of DGLA and its conversion to arachidonic acid (AA), at the Δ5 desaturation step were also depressed in SHR. We conclude that, in SHR, the alteration in polyunsaturated fatty acid (PUFA) metabolism may influence the synthesis of AA‐derived eicosanoids involved in the control of blood pressure regulation.