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Nucleotide sequence of a cDNA clone (SUBT1) partly homologous to a human subtelomeric repeat sequence
Author(s) -
Lagercrantz Jacob,
Lagercrantz Svetlana
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201321
Subject(s) - genbank , telomere , biology , subtelomere , genetics , complementary dna , clone (java method) , tandem repeat , nucleic acid sequence , genomic dna , microbiology and biotechnology , sequence (biology) , chromosome , dna , genome , gene
Abstract Telomeres contains short tandem repeats (TTAGGG)n that are usually several kilobases in size. DNA sequences located next to the repeats are called telomere‐associated or subtelomeric sequences. In this report we describe isolation and characterization of a new cDNA sequence isolated with a telomere specific, chromosome 17 genomic clone. No open reading frame of notable length could be detected. However comparison with sequences in the EMBL/Genbank revealed a 897 bp of close to perfect match, in the 3′ end with the centromeric end of a genomic clone containing subtelomeric repeat sequences. The potential function of the SUBT1 transcript remains to be elucidated.