Premium
Coenzyme Q depletion in rat plasma after partial hepatectomy
Author(s) -
Formiggini G.,
Castelluccio C.,
Pich M. Merlo,
Genova M. L.,
Bovina C.,
Marchetti M.,
Lenaz G.
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201312
Subject(s) - medicine , endocrinology , mitochondrion , hepatectomy , limiting , biology , biosynthesis , chemistry , biochemistry , enzyme , surgery , mechanical engineering , resection , engineering
Coenzyme Q content was monitored in blood plasma and regenerating liver mitochondria of hepatectomized rats, using as controls either sham‐operated or non‐operated animals. Mitochondrial CoQ9 content increased in sham‐operated rats, whilst it was significantly lower in hepatectomized in comparison with non‐operated animals at all considered times. On the other hand plasma CoQ9 levels dramatically decreased in hepatectomized animals, while strongly increased in sham‐operated in comparison with non‐operated rats. The quinone decrease in hepatectomized animals is likely to be due to the attainment of a rate‐limiting step in CoQ biosynthesis.