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Indole‐3‐carbinol as a scavenger of free radicals
Author(s) -
Arnao M. B.,
SanchezBravo J.,
Acosta M.
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201302
Subject(s) - indole test , radical , chemistry , free radical scavenger , scavenger , isatin , organic chemistry , antioxidant
The ability of indole‐3‐carbinol (indole‐3‐methanol) to trap a metastable synthetic‐free radical is presented. Indole‐3‐carbinol is capable of acting as a scavenger of free radicals in an in vitro system. The presence of indole‐3‐carbinol determines the disappearance of the free radicals, the reaction being time‐ and concentration‐dependent. The scavenging activity of different indoles is compared. Indole‐3‐carbinol and indole‐3‐acetic acid are both able to scavenge free radicals, but indole‐3‐carbinol is more effective. Other indoles such as indole‐3‐aldehyde and indole‐3‐carboxylic acid do not show the ability to trap free radicals. Indole‐3‐aldehyde appears as a product of indole‐3‐carbinol reaction with free radicals. The formation of an adduct between the free radical generated in vitro and indole‐3‐carbinol has also been detected. Stability of indole‐3‐carbinol in buffered media at different pH values and formation of 3,3′‐diindolylmethane from indole‐3‐carbinol is also studied. The scavenging activity of indole‐3‐carbinol and its implications on the anti‐carcinogenesis process is discussed.