Premium
Bovine papilomavirus oncoprotein E5 induces the NFκB activation through superoxide radicals
Author(s) -
Kilk Ann,
Talpsepp Tiit,
Väli Ülo,
Ustav Mart
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201293
Subject(s) - superoxide , open reading frame , reactive oxygen species , superoxide dismutase , nfkb1 , nf κb , microbiology and biotechnology , chemistry , p50 , kappa , radical , biology , gene , apoptosis , biochemistry , transcription factor , enzyme , peptide sequence , linguistics , philosophy
Bovine papillomavirus type 1 (BPV‐1) open reading frame E5 encodes the smallest known oncoprotein. This protein is involved in transforming cells during the early stage of infection. Nuclear factor κB (NFκB) is activated in the host cells as a result of different virus infections. It has been shown that reactive oxygen intermediates activate NFκB which leads to the activation of several cellular genes. We studied the effect of BPV‐1 E5 protein on NFκB activation. We found that low and moderate concentrations of E5 protein activate NFκB. This activation is suppressed by superoxide dismutase. We conclude that the superoxide anion is involved in activation of NFκB.