S‐(‐)‐nicotine‐1′‐N‐oxide reductase activity of rat liver aldehyde oxidase | Zendy

Sugihara Kazumi | Zendy; Kitamura Shigeyuki | Zendy; Tatsumi Kiyoshi | Zendy

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S‐(‐)‐nicotine‐1′‐N‐oxide reductase activity of rat liver aldehyde oxidase

Author(s) -

Sugihara Kazumi,

Kitamura Shigeyuki,

Tatsumi Kiyoshi

Publication year - 1996

Publication title -

iubmb life

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.132

H-Index - 113

eISSN - 1521-6551

pISSN - 1521-6543

DOI - 10.1080/15216549600201113

Subject(s) - nicotine , chemistry , enzyme , aldehyde reductase , aldehyde oxidase , reductase , aldehyde , cytosol , biochemistry , stereochemistry , medicine , xanthine oxidase , catalysis

In the present study, a rat liver cytosolic enzyme responsible for reduction of S‐(‐)‐nicotine‐1′‐N‐oxide to S‐(‐)‐nicotine was investigated. We found that aldehyde oxidase (EC 1.2.3.1) can function as a S‐(‐)‐nicotine‐1′‐N‐oxide reductase in the presence of its electron donor such as 2‐hydroxypyrimidine. The apparent Km and Vmax values of the enzyme for the N‐oxide were 0.24 mM and 30.3 nmol/10 min/mg protein, respectively.

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