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Dysplasia expresses altered nuclear matrix protein composition in human ulcerative colitis
Author(s) -
Izzo Richard S.,
Pellecchia Crescens
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201093
Subject(s) - ulcerative colitis , dysplasia , chemistry , pi , nuclear matrix , colitis , pathology , microbiology and biotechnology , medicine , gastroenterology , biology , biochemistry , dna , disease , chromatin
We compared nuclear matrix protein compositions (NMPS) in colonic tissue from three different patient groups: 1) normal controls; 2) ulcerative colitis (UC) and 3) ulcerative colitis with dysplasia (UC‐dysplasia). NMPS were separated by two‐dimensional electrophoresis using isoelectrofocusing and SDS‐PAGE. Six specific NMPS (59,500 Kd, pI 6.6 and 6.3; 49,250 Kd, pI 7.4; 33,750 Kd, pI 7.5; 20,000 Kd, pI 7.5; and 19,000 Kd, pI 6.3) were identified in UC‐dysplasia that were not found in normal controls nor in UC colonic tissue. These observations suggest that NMPS may serve as important biochemical markers of dysplasia in UC.