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Seizures induced by α‐guanidinoglutaric acid, a nitric oxide synthase inhibitor, are controlled by l‐arginine
Author(s) -
Habu Hitoshi,
Yokoi Isao,
Kabuto Hideaki,
Willmore L. James,
Mori Akitane
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201091
Subject(s) - nitric oxide synthase , convulsant , chemistry , nitric oxide , arginine , endogeny , pharmacology , substrate (aquarium) , atp synthase , biochemistry , enzyme , medicine , amino acid , biology , receptor , organic chemistry , ecology
We evaluated the effect of manipulation of nitric oxide (NO) synthesis on epileptiform discharges recorded from immobilized rats during intracerebro‐ventricular injection of α‐guanidinoglutaric acid (GGA), an endogenous convulsant and a NO synthase (NOS) inhibitor, alone or in combined with a NOS substrate, l‐arginine (ARG). GGA alone, or combined with 50 mM ARG, resulted in prolonged electrographical seizures while co‐injection of either 100 or 200 mM of ARG with GGA caused significantly protection. These data show that ARG inhibited epileptiform discharges in a dose‐dependent fashion, suggesting that the discharges initiated by inhibition of NOS with the intrinsic convulsant GGA are abated by increasing the concentration of the NOS substrate ARG.