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Attenuation by nicotinamide of the streptozocin induced early hyperglycaemia in fasting rats
Author(s) -
Wong Kai K.
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201083
Subject(s) - streptozocin , nicotinamide , endocrinology , medicine , diabetes mellitus , chemistry , biochemistry , streptozotocin , enzyme
The effect of nicotinamide on the streptozocin induced early hyperglycaemia in 48‐hour fasted rats was investigated. It was shown that 240 or 400 mg/kg nicotinamide significantly attenuated the streptozocin induced early hyperglycaemia. Nicotinamide should be administered no later than 1 hour after the streptozocin administration. Lower level doses of nicotinamide such as 80 mg/kg were unable to attenuate the streptozocin induced early hyperglycaemia. The possibility of nicotinamide offsetting the streptozocin effect was discussed.