Premium
Investigation of the effect of tetrahydroaminoacridine on turnover kinetics of camel (Camelus dromedarius) retina acetylcholinesterase
Author(s) -
AlJafari Abdulaziz A.,
Kamal Mohammad A.
Publication year - 1996
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549600201062
Subject(s) - acetylcholinesterase , enzyme kinetics , kinetics , aché , cholinesterase , chemistry , retina , endocrinology , medicine , enzyme , pharmacology , biochemistry , biology , neuroscience , active site , physics , quantum mechanics
The effect of tetrahydroaminoacridine (THA) on turnover kinetics of camel retina acetylcholinesterase has been investigated. The turnover number (Kcat) and specificity constant (Ksp) were 62.1 min‐1 and 9.92 × 105 (M. min)‐1 in the control system while the values for both parameters were lowered by 25‐68% and 48‐87% in the THA (0.05‐0.4 µM) treated systems respectively. Therefore, THA's effect on turnover number must be considered at the time of therapy to the Alzheimer's disease patients.