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The virtual human: Towards a global systems biology of multiscale, distributed biochemical network models
Author(s) -
Kell Douglas B.
Publication year - 2007
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540701694252
Subject(s) - sbml , workflow , computer science , systems biology , data science , distributed computing , modelling biological systems , scale (ratio) , markup language , computational biology , world wide web , biology , xml , physics , quantum mechanics , database
There is an emerging recognition of the importance of modelling large‐scale biochemical systems, with the ‘digital human’ an obviously desirable goal. This will then permit researchers to analyse the behaviour of such systems in silico so as to be able to perform ‘what‐if?’ experiments prior to determining whether they are actually worthwhile or not, and for understanding whether a particular model does in fact describe or predict experimental observations. Existing and developing standards such as SBML are beginning to permit the principled storage and exchange of biochemical network models, while environments for effecting distributed workflows (such as Taverna) will allow us to link together these models and their behaviour. This allows the local experts to work on those parts of cellular or organellar biochemistry on which they have most expertise, while making their results available to the community as a whole. This kind of architecture permits the distributed yet integrated goal of an evolving ‘digital human’ model to be realized. IUBMB Life, 59: 689‐695, 2007