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Implication of PKC in the seasonal variation of the immune response of the hemocytes of Mytilus galloprovincialis Lmk. and its role in interleukin‐2‐induced nitric oxide synthesis
Author(s) -
Novas Ana,
Barcia Ramiro,
RamosMartínez Juan Ignacio
Publication year - 2007
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540701553235
Subject(s) - mytilus , protein kinase c , bisindolylmaleimide , nitric oxide , immune system , biology , protein kinase a , microbiology and biotechnology , kinase , immunology , ecology , endocrinology
The hemocytes are the cells responsible for the immune response in marine mollusks. The role of NO in processes related to the activation of the hemocytes has turned out evident over the late years. In the case of the mussel Mytilus galloprovincialis Lmk., hemocyte NO basal production varies throughout the year, showing a maximum in summer and a minimum in winter. IL‐2 reverts the low winter NO basal production through a process mediated by cAMP‐dependent protein kinase and by an apparent side effect of protein kinase C. The seasonal variation of NO production in the presence of the PKC inhibitor bisindolylmaleimide (BSM) allows suggesting a model in which PKC would modulate the activity of the enzymes responsible for nitric oxide production. IUBMB Life, 59: 659‐663, 2007