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The mAKAP signalosome and cardiac myocyte hypertrophy
Author(s) -
Bauman Andrea L.,
Michel Jennifer J. Carlisle,
Henson Edward,
DodgeKafka Kimberly L.,
Kapiloff Michael S.
Publication year - 2007
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540701358593
Subject(s) - cardiac myocyte , crosstalk , signal transduction , microbiology and biotechnology , scaffold protein , myocyte , transcription factor , biology , protein kinase a , muscle hypertrophy , kinase , intracellular , endocrinology , biochemistry , gene , physics , optics
Cardiac hypertrophy is regulated by a large intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cell growth. In the last few years, it has become apparent that multimolecular signaling complexes or 'signalosomes' are important for mediating crosstalk between different signaling pathways. These complexes integrate upstream signals and control downstream effectors. In the cardiac myocyte, the protein mAKAPβ serves as a scaffold for a large signalosome that is responsive to upstream cAMP, Ca2+, and mitogen‐activated protein kinase signaling. The mAKAPβ signalosome is important for the control of NFATc transcription factor activity and for the overall induction of myocyte hypertrophy.IUBMB Life, 59: 163‐169, 2007